Monoamine neurotransmission is hypothesized to be decreased during depression.
Monoamine neurotransmitters, such as norepinephrine (NE) and dopamine (DA), are significant bioactive compounds in the central nervous system (CNS). Monoamine neurotransmitters play a role in a variety of physiological processes in the body, such as emotion, memory, and learning. The monoamine hypothesis or Monoamine neurotransmitters, its variations have ruled the area for the past few years. It is thought that the aetiology of depression is influenced by the malfunction of monoamine neurotransmitters, their metabolites, and the maladaptive alternations of their receptors in the CNS. Therefore, it is not unexpected that NE, 5-HT, and DA have long been the main targets of pharmacological research on CHM treatment of depression by Monoamine neurotransmitters. These substances can be found in the brain or serum.
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